THE FUTURE OF ONCOLOGY IS SYNERGETIC

FUSIONx is the first human-based marketplace for identifying and quantifying oncology drug synergies, accelerating the path to clinically meaningful combination therapies. 

HOW IT WORKS

01.

Host.

Pharma partners list an "Anchor Asset" challenge to upgrade drug performance.

02.

Nominate.

Biotech companies submit candidate compounds as potential matches.

03.

Validate.

We test combinations on our proprietary human-tissue platform to find the best match.

04.

Reward.

Powerful matches trigger financial rewards and partnership opportunities.

challenges

CHALLENGES

Perioperative Pivot: Elevating FLOT to New Heights in Resectable Gastric/GEJ Cancer

#01

Reward Amount: $400,000

Join this challenge to test your novel agent with the FLOT backbone in fresh gastric resection tissues, aiming to double pathological complete response (pCR) rates beyond the current ~7-19% and transform perioperative outcomes in a rapidly evolving market.

Entry Fee: $10,000.00

Epigenetic Spark: Igniting Immune Visibility in “Cold” MSS-Colorectal and SCLC Tumors

#02

Reward Amount: $400,000

Pair your innovative immunotherapy or STING agonist with low-dose decitabine to induce viral mimicry, turning immunologically cold tumors hot and potentially elevating response rates far beyond current limited efficacy in MSS-CRC and SCLC.

Entry Fee: $10,000.00

Intravesical Upgrade: Preventing Recurrence in Non-Muscle Invasive Bladder Cancer

#03

Reward Amount: $400,000

Nominate your targeted or muco-adhesive partner to combine with gemcitabine or mitomycin C, targeting the high recurrence rates (>40-50% at 5 years) in NMIBC and delivering a breakthrough in bladder-sparing therapy.

Entry Fee: $10,000.00

CLINICAL VALIDATION & CORE ENGINE

Powered by the CURESPONSE Functional Platform

Institutional Credentials

CE-marked and ISO-certified regulatory excellence.

Predictive Performance

Clinically validated with +90% prediction accuracy (PPV/NPV).

90%

Biological Differentiator

Captures full human tumor microenvironment (TME) dynamics, including stroma and immune cell architecture.

Universal Applicability

Validated across all solid tumors, therapy classes, and novel drug combinations.

Our Team

RONEN VINER

VP BUSINESS DEVELOPMENT

VERED BAR

CTO

FAQs

Frequently Asked Questions

What is a FUSIONx challenge?

Each challenge tests 8 biotech competitors per tissue (A-H) across 5 patient tissues for statistical significance. Success is ≥50% improvement in functional response score vs. control. We aim for ~40 participants per challenge, running phased batches. 

What testing platform do you use?

 We use CURESPONSE’s clinically validated, CE-marked ex-vivo system, which preserves full human tumor dynamics with high accuracy — far beyond traditional models.

What are the benefits for pharma (challenge hosts)?
  • Zero upfront cost — commit via milestone rewards.
  • $1M to FUSIONx per successful match; $1M (or equivalent) to the winning biotech, plus option rights or exclusive negotiation.
  • Elevate assets, extend product life, improve response rates, and access external innovation risk-free.
What are the benefits for biotechs (applicants)?
  • $10K entry (testing on 5 tissues; discounts for multiples).
  • Visibility to pharma, objective human-based validation, and clear rewards.
  • Huge upside: $400K prize on success, plus partnership options (see below).
  • Strategic perks: Direct BD opportunities, data-driven proof for fundraising.
What happens if we hit the synergy threshold?

You choose your path:

  • Prize + Partnership: $400K cash prize plus collaborate with FUSIONx on the combo asset (45% your company / 55% FUSIONx, reflecting our platform role and deadlock avoidance). The prize is awarded upon signing a simple partnership agreement.
  • Full Ownership: Retain 100% IP/ownership of the combo — no prize, but a modest milestone/royalty (5–10%) to FUSIONx for enabling the discovery. This ensures mutual commitment while giving you flexibility.
What if we're close but miss the threshold (40–50% improvement)?

You get free additional testing on 5 more tissues (your choice: combo or standalone) to refine and potentially qualify.

How do you ensure data ownership and confidentiality?

Biotechs own all non-synergy combo data and standalone results outright. We prioritize confidentiality in all testing and partnerships.

 
When will pharma-hosted challenges begin?

We’re launching with self-hosted interim challenges (using generic backbones) to build momentum. Pharma-hosted challenges will roll out soon after, based on early successes.

 
How can I get involved?

Biotechs: Nominate your asset via our application form. Pharma: Contact us to discuss hosting. 

 

Contact Us

Host a Challenge. Elevate your pipeline or commercial assets via synergistic combinations

The Terms