THE FUTURE OF ONCOLOGY IS SYNERGETIC
FUSIONx is the first human-based marketplace for identifying and quantifying oncology drug synergies, accelerating the path to clinically meaningful combination therapies.
HOW IT WORKS
01.
Host.
Pharma partners list an "Anchor Asset" challenge to upgrade drug performance.
02.
Nominate.
Biotech companies submit candidate compounds as potential matches.
03.
Validate.
We test combinations on our proprietary human-tissue platform to find the best match.
04.
Reward.
Powerful matches trigger financial rewards and partnership opportunities.
challenges
CHALLENGES
Perioperative Pivot: Elevating FLOT to New Heights in Resectable Gastric/GEJ Cancer
Reward Amount: $400,000
Entry Fee: $10,000.00
Epigenetic Spark: Igniting Immune Visibility in “Cold” MSS-Colorectal and SCLC Tumors
Reward Amount: $400,000
Entry Fee: $10,000.00
Intravesical Upgrade: Preventing Recurrence in Non-Muscle Invasive Bladder Cancer
Reward Amount: $400,000
Entry Fee: $10,000.00
CLINICAL VALIDATION & CORE ENGINE
Powered by the CURESPONSE Functional Platform
Institutional Credentials
CE-marked and ISO-certified regulatory excellence.
Predictive Performance
Clinically validated with +90% prediction accuracy (PPV/NPV).
90%
Biological Differentiator
Captures full human tumor microenvironment (TME) dynamics, including stroma and immune cell architecture.
Universal Applicability
Validated across all solid tumors, therapy classes, and novel drug combinations.
FAQs
Frequently Asked Questions
Each challenge tests 8 biotech competitors per tissue (A-H) across 5 patient tissues for statistical significance. Success is ≥50% improvement in functional response score vs. control. We aim for ~40 participants per challenge, running phased batches.
We use CURESPONSE’s clinically validated, CE-marked ex-vivo system, which preserves full human tumor dynamics with high accuracy — far beyond traditional models.
- Zero upfront cost — commit via milestone rewards.
- $1M to FUSIONx per successful match; $1M (or equivalent) to the winning biotech, plus option rights or exclusive negotiation.
- Elevate assets, extend product life, improve response rates, and access external innovation risk-free.
- $10K entry (testing on 5 tissues; discounts for multiples).
- Visibility to pharma, objective human-based validation, and clear rewards.
- Huge upside: $400K prize on success, plus partnership options (see below).
- Strategic perks: Direct BD opportunities, data-driven proof for fundraising.
You choose your path:
- Prize + Partnership: $400K cash prize plus collaborate with FUSIONx on the combo asset (45% your company / 55% FUSIONx, reflecting our platform role and deadlock avoidance). The prize is awarded upon signing a simple partnership agreement.
- Full Ownership: Retain 100% IP/ownership of the combo — no prize, but a modest milestone/royalty (5–10%) to FUSIONx for enabling the discovery. This ensures mutual commitment while giving you flexibility.
You get free additional testing on 5 more tissues (your choice: combo or standalone) to refine and potentially qualify.
Biotechs own all non-synergy combo data and standalone results outright. We prioritize confidentiality in all testing and partnerships.
We’re launching with self-hosted interim challenges (using generic backbones) to build momentum. Pharma-hosted challenges will roll out soon after, based on early successes.
Biotechs: Nominate your asset via our application form. Pharma: Contact us to discuss hosting.
Contact Us
Host a Challenge. Elevate your pipeline or commercial assets via synergistic combinations
The Terms
- Zero upfront costs for scouting.
- FUSIONx handles all intake and logistics.
- Pharma host defines the "Success Criteria" and the "Reward" for the winning match.
- Standardized MTA/CDA to ensure IP security from Day 1.

